Unit 8: Gastrointestinal Pharmacology

There is a diverse range of medications utilized in the management of gastrointestinal disorders. Certain categories of drugs are primarily designated for the treatment of GI conditions. In this unit, our focus will be on primary care, and we will not delve into intravenous formulations. Our emphasis remains on understanding clinical use, dosing, rational drug selection, and patient education, much like in previous units.

Primary care practitioners frequently encounter a variety of GI disorders, including gastroesophageal reflux disease and peptic ulcer disease. Over-the-counter medications have become increasingly available for treating these conditions in recent years. Nevertheless, it is essential to grasp the underlying pathophysiology and recognize instances when over-the-counter treatments are ineffective. We will also explore stepwise approaches to care and considerations for special populations.

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Career Goals: Strengths and Challenges Related to Nursing Practice Competencies

Unit Learning Objectives
1. Scrutinize the principles of pathophysiology and therapeutics guiding pharmacotherapeutic interventions affecting the gastrointestinal system.
2. Analyze the pharmacokinetic and pharmacodynamic actions of agents influencing the gastrointestinal system.
3. Apply critical-thinking processes to manage and assess the expected effects, potential adverse effects, and interactions of pharmacological agents impacting the gastrointestinal system.
4. Implement evidence-based pharmacotherapeutic interventions for patients with gastrointestinal system disorders.
5. Assess the influence of pharmacogenomics, access, cost, quality, and safety on prescribing drugs affecting the Gastrointestinal System.

Week 10/Unit 8 “To Do” List
– Complete High-Yield Med Review Quiz by Sunday Week 10
– Unit 6 & 7 Exam available Thursday 11/10 to Saturday 11/12 (Access via Respondus)

Learning Materials

Learning Materials
Lectures & E-Book
Busti, A. J. (2022). NP Curriculum Support-Advanced Pharmacology for NPs. MedEducation, LLC.
GASTROINTESTINAL PHARMACOLOGY
– 5-ASA Derivatives
– Antacids
– Antidiarrheals
– Antiemetics
– Fiber, laxatives, Stool Softeners
SPECIAL TOPICS IN PHARMACOLOGY
– Drug Food Interactions
– Drug Gastric Acid Interactions

Optional Learning Resources:
Media
Parkes, C. (2019a, June 26). Nursing pharmacology – H2 receptor antagonists, PPIs, sucralfate, antacids, prostaglandins [Video]. YouTube. https://www.youtube.com/watch?v=tYnSDaHQNhM
Parkes, C. (2019b, June 26). Nursing pharmacology – antiemetic, antidiarrhea medications and prokinetic agents [Video]. YouTube. https://www.youtube.com/watch?v=vmbfLsNbMpk

Websites
Khan Academy. (2018a). Advanced gastrointestinal physiology. Retrieved March 11, 2021, from https://www.khanacademy.org/science/health-and-medicine/gastro-intestinal-system
Khan Academy. (2018c). Gastrointestinal system diseases. Retrieved March 11, 2021, from https://www.khanacademy.org/science/health-and-medicine/gastrointestinal-system-diseases

HYMR Quiz – GI
Following review of all assigned lectures and correlating E-book chapters in High Yield Med Review, you will complete the module quiz in the HYMR platform.
– From the Dashboard select “EXAMS”
– Navigate to the “GI-Self Assessment”
– Click “Take Exam”
You will have one attempt to complete 5 questions in 10 minutes. Once completed, please take a screen shot of your score and upload to this assignment tab for grading. This quiz is worth 20 points, so based on your % score you will receive the correlating points below.
– 100% 20 points
– 90% 18 points
– 80% 16 points
– 70% 14 points
– 60% 12 points
– 50% 10 points
– 40% 8 points
– 30% 6 points
– 20% 4 points
– 10% 2 points
– No submission 0 points
*Please note, faculty are able to view your time and activity in HYMR.*

Unit Conclusion

Unit Conclusion
As we conclude unit 8 of Advanced Pharmacology, we have explored the extensive array of medications employed in the treatment of gastrointestinal disorders. Our study has delved into the in-depth management of GI disorders. It is crucial to bear in mind stepwise approaches to care and considerations for special populations when prescribing medications. Remember that rational drug selection involves focusing on resolving or treating the underlying disease state while minimizing side effects.